H. Anne Pereira, Ph.D.

Dean, Graduate College and David L. Boren Professor

Pharmaceutical Sciences

Phone (405) 271-6593 x58034

Fax (405) 271-7505

Office CPB 329

Email anne-pereira@ouhsc.edu

Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.


Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Patents

Biomarker and method for detecting a chronic inflammatory-associated disease

Patent No. 8,450,071

USA

H. Anne Pereira


Publications & Presentations

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    1. Kasus-Jacobi A, Washburn J L, Laurence R B, Pereira A. Selecting Multitarget Peptides for Alzheimer's Disease. Biomolecules. 2022; 12 : 1386

    2. Kasus-Jacobi A, Washburn J, Land C, Pereira A. Neutrophil Granule Proteins Inhibit Amyloid Beta Aggregation and Neurotoxicity. Current Alzheimer Research. 2021; 18 : 414-427

    3. Kasus-Jacobi A, Land C, Stock A, Washburn J, Pereira A. Antimicrobial peptides derived from the immune defense protein CAP37 inhibit TLR4 activation by S100A9. Investigative Ophthalmology & Visual Science/Association for Research in Vision and Ophthalmology. 2020

    4. Stock A J, Kasus-Jacobi A, Pereira A. The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease. Journal of neuroinflammation. 2018; 15 : 240

    5. Kasus-Jacobi A, Griffith G L, Lerner M, Pereira A. Effect of Cationic Antimicrobial Protein CAP37 on Cytokine Profile during Corneal Wound Healing. Journal of Ocular Diseases and Therapeutics. 2017; 5 : 19-27

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Grants

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    16. 49th Annual Meeting of the Society for Leukocyte Biology - Inflammation, Immunity and Cancer: Neutrophils and Other leukocytes. NIH. Start Date: 2016. End Date: 2017.

    17. Molecular Basis of Immunity. NIH. Start Date: 2012. End Date: 2017.

    18. Novel topical peptide therapeutic for the treatment of wounds infected with antibiotic resistant Gram negative bacteria. Non-federal. Start Date: 2016. End Date: 2017.

    19. Wound healing mechanisms modulated by novel antimicrobial peptide. Misc Non-Federal. Start Date: 2015. End Date: 2016.

    20. 48th Annual Meeting of the Society for leukocyte Biology - Immunity in Health and Disease. NIH. Start Date: 2015. End Date: 2016.

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Awards and Honors

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                                                                                            16. American Lung Association. American Lung Association Research Award. Date: 1990.  

                                                                                            17. Gordon Research Conference on Phagocytes, New Hampshire. Travel Scholarship. Date: 1987.  

                                                                                            18. University of Melbourne, Australia. BSc (Honours) First Class Honours and First Place. Date: 1977.  

                                                                                            19. Commonwealth of Australia. Commonwealth Postgraduate Research Award. Date: 1977.  

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Education
 
                               
                                                            
                        
                                                                                            1.  Degree: Ph D. University of Melbourne. Date: 1982.  

                                                                                            2.  Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.  

                                                                                            3.  Degree: BS. University of Melbourne. Date: 1975.  




                        		 
                                                                                  
                        
                                                                               
 
                   
 
                
     
                
                 	                                        
                    
                                            	                           
                                                
                                                                                                                                                                               
Administrative Assignments

                                  
                                                           
                        
                                                
     1. Role: Dean. Scope: University. Description: Dean of the Graduate College. Responsible for Graduate Programs on the Health Sciences Campus and the Postdoctoral Office. Date: 2014.
                                                
     2. Role: Associate Dean. Scope: College. Description: Responsible for Oversight of research activities in the College of Pharmacy, mentoring junior faculty and trainees. Date: 2009.