1. Role: Dean. Scope: University. Description: Dean of the Graduate College. Responsible for Graduate Programs on the Health Sciences Campus and the Postdoctoral Office. Date: 2014.
H. Anne Pereira, Ph.D.
Dean, Graduate College and David L. Boren Professor
Pharmaceutical Sciences
Phone (405) 271-6593 x58034
Fax (405) 271-7505
Office CPB 329
Email anne-pereira@ouhsc.edu
Summary
My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.
Research
This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.
Patents
Biomarker and method for detecting a chronic inflammatory-associated disease
Patent No. 8,450,071
USA
H. Anne Pereira
Publications & Presentations
- 36. Pereira H A. CAP37, a neutrophil-derived multifunctional inflammatory mediator. Journal of leukocyte biology. 1995; 57 : 805-12
37. Pereira H A, Erdem I, Pohl J, Spitznagel J K. Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes. Proceedings of the National Academy of Sciences of the United States of America. 1993; 90 : 4733-7
38. Morgan J G, Sukiennicki T, Pereira H A, Spitznagel J K, Guerra M E, Larrick J W. Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. Journal of immunology (Baltimore, Md. : 1950). 1991; 147 : 3210-4
39. Morgan J G, Pereira H A, Sukiennicki T, Spitznagel J K, Larrick J W. Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases. Advances in experimental medicine and biology. 1991; 305 : 89-96
40. Pohl J, Pereira H A, Martin N M, Spitznagel J K. Amino acid sequence of CAP37, a human neutrophil granule-derived antibacterial and monocyte-specific chemotactic glycoprotein structurally similar to neutrophil elastase. FEBS letters. 1990; 272 : 200-4
Grants
- 16. 49th Annual Meeting of the Society for Leukocyte Biology - Inflammation, Immunity and Cancer: Neutrophils and Other leukocytes. NIH. Start Date: 2016. End Date: 2017.
17. Molecular Basis of Immunity. NIH. Start Date: 2012. End Date: 2017.
18. Novel topical peptide therapeutic for the treatment of wounds infected with antibiotic resistant Gram negative bacteria. Non-federal. Start Date: 2016. End Date: 2017.
19. Wound healing mechanisms modulated by novel antimicrobial peptide. Misc Non-Federal. Start Date: 2015. End Date: 2016.
20. 48th Annual Meeting of the Society for leukocyte Biology - Immunity in Health and Disease. NIH. Start Date: 2015. End Date: 2016.
Awards and Honors
- 11. American Heart Association. Established Investigator. Date: 1998.
12. OUHSC. Provosts' Research Award to Junior Faculty. Date: 1994.
13. American Lung Association. American Lung Association Research Award. Date: 1990.
14. Gordon Research Conference on Phagocytes, New Hampshire. Travel Scholarship. Date: 1987.
15. University of Melbourne, Australia. BSc (Honours) First Class Honours and First Place. Date: 1977.
Education
- 1. Degree: Ph D. University of Melbourne. Date: 1982.
2. Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.
3. Degree: BS. University of Melbourne. Date: 1975.
Administrative Assignments
2. Role: Associate Dean. Scope: College. Description: Responsible for Oversight of research activities in the College of Pharmacy, mentoring junior faculty and trainees. Date: 2009.