1. Role: Dean. Scope: University. Description: Dean of the Graduate College. Responsible for Graduate Programs on the Health Sciences Campus and the Postdoctoral Office. Date: 2014.
H. Anne Pereira, Ph.D.
Dean, Graduate College and David L. Boren Professor
Pharmaceutical Sciences
Phone (405) 271-6593 x58034
Fax (405) 271-7505
Office CPB 329
Email anne-pereira@ouhsc.edu
Summary
My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.
Research
This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.
Patents
Biomarker and method for detecting a chronic inflammatory-associated disease
Patent No. 8,450,071
USA
H. Anne Pereira
Publications & Presentations
- 41. Pereira H A, Spitznagel J K, Winton E F, Shafer W M, Martin L E, Guzman G S, Pohl J, Scott R W, Marra M N, Kinkade, Jr J M. The ontogeny of a 57-Kd cationic antimicrobial protein of human polymorphonuclear leukocytes: localization to a novel granule population. Blood. 1990; 76 : 825-34
42. Pereira H A, Shafer W M, Pohl J, Martin L E, Spitznagel J K. CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. The Journal of clinical investigation. 1990; 85 : 1468-76
43. Pereira H A, Spitznagel J K, Pohl J, Wilson D E, Morgan J, Palings I, Larrick J W. CAP 37, a 37 kD human neutrophil granule cationic protein shares homology with inflammatory proteinases. Life sciences. 1990; 46 : 189-96
44. Pereira H A, Martin L E, Spitznagel J K. Quantitation of a cationic antimicrobial granule protein of human polymorphonuclear leukocytes by ELISA. Journal of immunological methods. 1989; 117 : 115-20
45. Spitznagel J K, Pereira H A, Martin L E, Guzman G S, Shafer W M. A monoclonal antibody that inhibits the antimicrobial action of a 57 KD cationic protein of human polymorphonuclear leukocytes. Journal of immunology (Baltimore, Md. : 1950). 1987; 139 : 1291-6
Grants
- 16. 49th Annual Meeting of the Society for Leukocyte Biology - Inflammation, Immunity and Cancer: Neutrophils and Other leukocytes. NIH. Start Date: 2016. End Date: 2017.
17. Molecular Basis of Immunity. NIH. Start Date: 2012. End Date: 2017.
18. Novel topical peptide therapeutic for the treatment of wounds infected with antibiotic resistant Gram negative bacteria. Non-federal. Start Date: 2016. End Date: 2017.
19. Wound healing mechanisms modulated by novel antimicrobial peptide. Misc Non-Federal. Start Date: 2015. End Date: 2016.
20. 48th Annual Meeting of the Society for leukocyte Biology - Immunity in Health and Disease. NIH. Start Date: 2015. End Date: 2016.
Awards and Honors
- 6. American Association for the Advancement of Sciences (AAAS)Fellow. Date: 2014.
7. OUHSC. Henry Zarrow Presidential Professorship. Date: 2008.
8. Grace & Franklin Bernsen Foundation. Finalist, Grace & Franklin Bernsen Foundation Most Promising New Business Award. Date: 2007.
9. The Journal Record. On the Brink, Award for Innovation. Date: 2006.
10. Department of Pathology. Fred G Silva Research Award. Date: 1999.
Education
- 1. Degree: Ph D. University of Melbourne. Date: 1982.
2. Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.
3. Degree: BS. University of Melbourne. Date: 1975.
Administrative Assignments
2. Role: Associate Dean. Scope: College. Description: Responsible for Oversight of research activities in the College of Pharmacy, mentoring junior faculty and trainees. Date: 2009.