H. Anne Pereira, Ph.D.

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Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.

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Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.

Patents

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Publications & Presentations

16. Kasus-Jacobi A, Nag O, Awasthi V, Babizhayev M, Pereira A. Investivating carcinine transport and the expression profile of transporter genes in human corneal epithelial cells. Springer. 2015

17. Griffith G L, Kasus-Jacobi A, Lerner M R, Pereira A. Corneal wound healing, a newly identified function of CAP37, is mediated by protein kinase C delta (PKCδ). Investigative ophthalmology & visual science. 2014; 55 : 4886-95

18. Griffith G L, Russell R A, Kasus-Jacobi A, Pereira A. CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis. IOVS. 2013

19. Pereira H A, Tsyshevskaya-Hoover I, Hinsley H, Logan S, Nguyen M, Nguyen T T, Pohl J, Wozniak K, Fidel P L. Candidacidal activity of synthetic peptides based on the antimicrobial domain of the neutrophil-derived protein, CAP37. Medical mycology. 2010; 48 : 263-72

20. Gordon Y J, Romanowski E G, Shanks R M, Yates K A, Hinsley H, Pereira H A. CAP37-derived antimicrobial peptides have in vitro antiviral activity against adenovirus and herpes simplex virus type 1. Current eye research. 2009; 34 : 241-9

Grants

11. Oklahoma COBRE in Structural Biology – Phase II. NIH. Start Date: 2017. End Date: 2019.

12. Wound Healing Mechanisms Modulated by Novel Antimicrobial Peptides. NIH. Start Date: 2016. End Date: 2019.

13. 51st Annual Meeting of the Society for Leukocyte Biology (SLB) – Myeloid Cells: Development, Environment and Inflammation. NIH. Start Date: 2018. End Date: 2019.

14. 50th Annual Meeting of the Society for Leukocyte Biology – Leukocyte Memory: Health and Disease. NIH. Start Date: 2017. End Date: 2018.

15. Oklahoma Shared Clinical & Translational Resources. NIH. Start Date: 2013. End Date: 2018.

Awards and Honors

1. University of Oklahoma Health Sciences Center. David L Boren Professorship. Date: 2018.


2. College of Pharmacy. Herbert and Dorothy Langsam Chair. Date: 2018.


3. Oklahoma BioScience Association. OK Bio Researcher Recognition Award -Winner. Date: 2016.


4. Journal Record. Journal Record Innovator of the Year. Date: 2016.


5. National Academy of Inventors. Fellow. Date: 2015.

Education

1. Degree: Ph D. University of Melbourne. Date: 1982.


2. Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.


3. Degree: BS. University of Melbourne. Date: 1975.

Administrative Assignments

1. Role: Dean. Scope: University. Description: Dean of the Graduate College. Responsible for Graduate Programs on the Health Sciences Campus and the Postdoctoral Office. Date: 2014.
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2. Role: Associate Dean. Scope: College. Description: Responsible for Oversight of research activities in the College of Pharmacy, mentoring junior faculty and trainees. Date: 2009.
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