Amanda L. Sharpe, Ph.D.

Assistant Professor

Pharmaceutical Sciences

Phone (405) 271-6593 x47243

Fax (405) 271-7505



List of current grants

The Sharpe lab is interested in understanding the contribution of neuropeptides such as proopiomelanocortin, neurotensin, and corticotropin releasing factor to addiction, obesity, and age-related cognitive impairment, and in the development of therapeutics to treat these conditions. We use behavioral (operant conditioning), anatomical, pharmacological, and molecular approaches to address our research questions, often in combination with genetic mouse models. We are interested in the normal physiological role for these neuropeptides, as well as the adaptations that occur in this neurocircuitry under the conditions of obesity, food restriction, and chronic drug use. The long-term goals of our lab are to 1) elucidate the pharmacology and neurocircuitry involved in the regulation of appetite for and consumption of rewards (both food and drug), and 2) to determine the contribution of hypothalamic neuropeptides to age-related conditions such as obesity and cognitive decline.

Education & Experience

B.S. in Pharmacy

Ohio Northern University, Ada, OH


Ph.D. in Pharmacology

Wake Forest University, Winston-Salem, NC


Postdoc in Behavioral Neuroscience

Oregon Health & Science University, Portland, OR



Effect of obesity on proopiomelanocortin regulation of reward and feeding

Presbyterian Health Foundation

07/01/2018 - 06/30/2019

Effects of dietary restriction on age-related neurophysiological adaptations: From behavior to single dopaminergic neurons

Oklahoma Medical Research Foundation

05/01/2018 - 04/30/2021

Publications & Presentations

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    11. Sharpe A, Calderon A S, Andrade M A, Cunningham J T, Mifflin S W, Toney G M. Chronic intermittent hypoxia increases sympathetic control of blood pressure: role of neuronal activity in the hypothalamic paraventricular nucleus. American journal of physiology. Heart and circulatory physiology. 2013; 305 : H1772-80

    12. Branch S Y, Goertz R B, Sharpe A, Pierce J, Roy S, Ko D, Paladini C A, Beckstead M J. Food restriction increases glutamate receptor-mediated burst firing of dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013; 33 : 13861-72

    13. Sharpe A, Andrade M A, Herrera-Rosales M, Britton S L, Koch L G, Toney G M. Rats selectively bred for differences in aerobic capacity have similar hypertensive responses to chronic intermittent hypoxia. American journal of physiology. Heart and circulatory physiology. 2013; 305 : H403-9

    14. Sharpe A, Klaus J D, Beckstead M J. Meal schedule influences food restriction-induced locomotor sensitization to methamphetamine. Psychopharmacology. 2012; 219 : 795-803

    15. Pastor R, Reed C, Burkhart-Kasch S, Li N, Sharpe A, Coste S C, Stenzel-Poore M P, Phillips T J. Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing factor type 1 and double type 1 and 2 receptor knockout mice. Psychopharmacology. 2011; 218 : 169-77

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