Aditya D. Joshi, Ph.D.

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Summary

My research is focused on understanding Aryl hydrocarbon Receptor (AhR) signaling in normal liver physiology as well as in plethora of hepatic and metabolic diseases. The AhR is a ligand-activated transcription factor, historically studied in the context of exogenous ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) induced toxicity. We have demonstrated that in contrast to the toxicity exhibited by exogenous AhR agonists, the endogenous AhR ligand, cinnabarinic acid induced expression of AhR target gene, stanniocalcin 2 is responsible for hepatoprotection against chemical, environmental and pharmacological stressors both in vitro and in vivo. Our long-term objectives are to mechanistically study repertoire of AhR target genes in the context of liver and metabolic diseases and to develop a translational approach to AhR biology by identifying and characterizing therapeutically useful endogenous AhR agonists to ameliorate hepatic injury. To achieve our long-term goal my research employs cutting-edge cellular, molecular and biochemical methodologies as well as utilizes innovative genome-wide technologies such as next-generation sequencing (RNA, ChIP and ATAC-seq) and CRISPR mediated genome editing. 

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Publications & Presentations

21. Lanner J T, Georgiou D K, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi A, Chen Z, Yarotskyy V, Oakes J M, Lee C S, Monroe T O, Santillan A, Dong K, Goodyear L, Ismailov I I, Rodney G G, Dirksen R T, Hamilton S L. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nature medicine. 2012; 18 : 244-51

22. Pajor A M, Sun N N, Joshi A, Randolph K M. Transmembrane helix 7 in the Na+/dicarboxylate cotransporter 1 is an outer helix that contains residues critical for function. Biochimica et biophysica acta. 2011; 1808 : 1454-61

23. Lanner J T, Georgiou D K, Joshi A, Hamilton S L. Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harbor perspectives in biology. 2010; 2 : a003996

24. Joshi A, Pajor A M. Identification of conformationally sensitive amino acids in the Na(+)/dicarboxylate symporter (SdcS). Biochemistry. 2009; 48 : 3017-24

25. Joshi A, Pajor A M. Role of conserved prolines in the structure and function of the Na+/dicarboxylate cotransporter 1, NaDC1. Biochemistry. 2006; 45 : 4231-9

Grants

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Awards and Honors

1. Society of Toxicology. Mechanism Specialty Section Research Award. Date: 2015.


2. Society of Toxicology. Molecular and Systems Biology Specialty Section Research Award. Date: 2015.


3. Society of Toxicology. Dr. Dharm Singh Award. Date: 2013.


4. Society of Toxicology. Molecular Biology Specialty Section Research Award. Date: 2013.


5. University of Texas Medical Branch. Mason Guest Award in Physiology and Biophysics . Date: 2006.

Education

1. Degree: Ph D. University of Texas Medical Branch. Date: 2008.


2. Degree: MS. University of Mumbai. Date: 2002.


3. Degree: BS. University of Mumbai. Date: 2000.

Administrative Assignments

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