Aditya D. Joshi, Ph.D.

Assistant Professor

Pharmaceutical Sciences

Phone 405-271-6593 x 47471

Fax 405-271-7505


Faculty Website


My research is focused on understanding Aryl hydrocarbon Receptor (AhR) signaling in normal liver physiology as well as in plethora of hepatic and metabolic diseases. The AhR is a ligand-activated transcription factor, historically studied in the context of exogenous ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) induced toxicity. We have demonstrated that in contrast to the toxicity exhibited by exogenous AhR agonists, the endogenous AhR ligand, cinnabarinic acid induced expression of AhR target gene, stanniocalcin 2 is responsible for hepatoprotection against chemical, environmental and pharmacological stressors both in vitro and in vivo. Our long-term objectives are to mechanistically study repertoire of AhR target genes in the context of liver and metabolic diseases and to develop a translational approach to AhR biology by identifying and characterizing therapeutically useful endogenous AhR agonists to ameliorate hepatic injury. To achieve our long-term goal my research employs cutting-edge cellular, molecular and biochemical methodologies as well as utilizes innovative genome-wide technologies such as next-generation sequencing (RNA, ChIP and ATAC-seq) and CRISPR mediated genome editing. 

Publications & Presentations

<< 1 2 3 4 5 > >>
    11. Joshi A, Mustafa M G, Lichti C F, Elferink C J. Homocitrullination Is a Novel Histone H1 Epigenetic Mark Dependent on Aryl Hydrocarbon Receptor Recruitment of Carbamoyl Phosphate Synthase 1. The Journal of biological chemistry. 2015; 290 : 27767-78

    12. Jackson D P, Joshi A, Elferink C J. Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs. Toxicology research. 2015; 4 : 1143-1158

    13. Joshi A, Carter D E, Harper, Jr T A, Elferink C J. Aryl hydrocarbon receptor-dependent stanniocalcin 2 induction by cinnabarinic acid provides cytoprotection against endoplasmic reticulum and oxidative stress. The Journal of pharmacology and experimental therapeutics. 2015; 353 : 201-12

    14. Lee C S, Georgiou D K, Dagnino-Acosta A, Xu J, Ismailov I I, Knoblauch M, Monroe T O, Ji R, Hanna A D, Joshi A, Long C, Oakes J, Tran T, Corona B T, Lorca S, Ingalls C P, Narkar V A, Lanner J T, Bayle J H, Durham W J, Hamilton S L. Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function. The Journal of biological chemistry. 2014; 289 : 25556-70

    15. Jackson D P, Li H, Mitchell K A, Joshi A, Elferink C J. Ah receptor-mediated suppression of liver regeneration through NC-XRE-driven p21Cip1 expression. Molecular pharmacology. 2014; 85 : 533-41

<< 1 2 3 4 5 > >>


no results

Awards and Honors

1 2 >>
                                                                                            1. Society of Toxicology. Mechanism Specialty Section Research Award. Date: 2015.  

                                                                                            2. Society of Toxicology. Molecular and Systems Biology Specialty Section Research Award. Date: 2015.  

                                                                                            3. Society of Toxicology. Dr. Dharm Singh Award. Date: 2013.  

                                                                                            4. Society of Toxicology. Molecular Biology Specialty Section Research Award. Date: 2013.  

                                                                                            5. University of Texas Medical Branch. Mason Guest Award in Physiology and Biophysics . Date: 2006.  

1 2 >>


                                                                                            1.  Degree: Ph D. University of Texas Medical Branch. Date: 2008.  

                                                                                            2.  Degree: MS. University of Mumbai. Date: 2002.  

                                                                                            3.  Degree: BS. University of Mumbai. Date: 2000.