Wei Yue, Ph.D.

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Summary

My research program focuses on studying novel mechanisms involved in regulation of OATP1B1 and OATP1B3 transport function. The long-term goal of my laboratory is to establish a mechanistic model to predict OATP-mediated drug-drug interactions, toxicities and inter-individual variability in drug response. Multi-disciplinary approaches are utilized including: 1) Sandwich-cultured primary human hepatocytes model; 2) Physiologically based pharmacokinetic (PBPK) modeling approach to assess clinically relevant DDIs; 3) Pharmacogenomics studies of drug transport proteins; 4) Post-translational regulation of OATP transporters; 5) Confocal microscopy to study trafficking of the transport proteins.

Academic Awards

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Publications & Presentations

11. Crowe A, Yue W. Semi-quantitative determination of protein expression using immunohistochemistry staining and analysis: an integrated protocol. Bio-Protocol. 2019

12. Liu Q, Keyesh R, Farasyn T, Li Y, Vu N, Kupiec T, Yue W. A sensitive quantification method of unbound vemurafenib in human plasma using equilibrium dialysis followed by ultra-performance liquid chromatography coupled to a tandem mass spectrometry. PharmSci 360-AAPS Annual Meeting. 2019

13. Kayesh R, Farasyn T, Crowe A, Liu Q, Pahwa S, Alam K, Ding K, Neuhoff S, Hatley O, Yue W. Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using static and physiologically based pharmacokinetic models. PharmSci 360-AAPS Annual Meeting. 2019

14. Wang L, Yue W, Hu M. Cellular uptake kinetic studies of Wogonoside, Luteolin 3’-glucuronide and apigenin 7-glucuronide in OATP1B1, 1B3 and 2B1 overexpressed HEK-293 cell lines. PharmSci 360-AAPS Annual Meeting. 2019

15. Crowe A, Miller J, Yue W. Genotyping of the OATP1B1 c. 521 T>C polymorphism from the Formalin-Fixed Paraffin-Embedded (FFPE) tissue specimens: an optimized protocol. Bio-Protocol. 2019; 9

Grants

1. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . NIH. Start Date: 2022. End Date: 2026.

2. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . Misc Non-Federal. Start Date: 2022. End Date: 2022.

3. Lysine Acetylation: A novel mechanism governing organic anion transporting polypeptides OATP1B1- and OATP1B3-mediated transport. Misc Non-Federal. Start Date: 2021. End Date: 2022.

4. Elucidating novel mechanism underlying OATP1B1/1B3-mediated drug-drug interactions . Non-federal. Start Date: 2019. End Date: 2020.

5. Characterize ADME of compound X. Non-federal. Start Date: 2019. End Date: 2020.

Awards and Honors

1. WiSDMH at OUHSC. Recognition of OUHSC Women in Science Dentistry Medicine and Health. Date: 2022.


2. Shandong University, China. Sunshine scholarship. Date: 1996.

Education

1. Degree: Postdoctoral training. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Date: 2008.


2. Degree: Postdoctoral Training. Lineberger Comprehensive Cancer Center, Univeristy of North Carolina at Chapel Hill. Date: 2007.


3. Degree: Ph D. Peking Union Medical College and Shandong University, China. Date: 2001.


4. Degree: MS. Shandong University, China. Date: 1998.


5. Degree: BS. Shandong Agricultural University, China. Date: 1995.

Administrative Assignments

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