Wei Yue, Ph.D.

Associate Professor

Pharmaceutical Sciences

Phone (405) 271-6593 x47828

Fax (405) 271-7505

Office CPB 328

Email wei-yue@ouhsc.edu

Faculty Website https://sites.google.com/view/yuelab


Summary

My research program focuses on studying novel mechanisms involved in regulation of OATP1B1 and OATP1B3 transport function. The long-term goal of my laboratory is to establish a mechanistic model to predict OATP-mediated drug-drug interactions, toxicities and inter-individual variability in drug response. Multi-disciplinary approaches are utilized including: 1) Sandwich-cultured primary human hepatocytes model; 2) Physiologically based pharmacokinetic (PBPK) modeling approach to assess clinically relevant DDIs; 3) Pharmacogenomics studies of drug transport proteins; 4) Post-translational regulation of OATP transporters; 5) Confocal microscopy to study trafficking of the transport proteins.



Academic Awards

Member, Educators for Excellence

OUHSC

April 2022


Publications & Presentations

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    1. Yue W, Farasyn T, Crowe A, Alam K, Garcia-Contreras L, Tu Y, Wang L. Transporters in hepatic and intestinal uptake of orally administered drugs. John Wiley & Sons, Inc. 2024

    2. Powell J T, Kayesh R, Ballesteros-Perez A, Alam K, Niyonshuti P, Soderblom E J, ding k, Xu C, Yue W. Assessing Trans-Inhibition of OATP1B1 and OATP1B3 by Calcineurin and/or PPIase Inhibitors and Global Identification of OATP1B1/3-Associated Proteins. Pharmaceutics. 2024; 16 : 63

    3. Kayesh R, Tambe V, Xu C, Yue W. Differential Preincubation Effects of Nicardipine on OATP1B1- and OATP1B3-Mediated Transport in the Presence and Absence of Protein: Implications in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions. Pharmaceutics. 2023; 15 : 1020

    4. Brouwer K, Evers R, Hayden E, Hu S, Yanfei Li C, Meyer zu Schwabedissen H, Neuhoff S, Oswald S, Piquette-Miller M, Saran C, Sjöstedt N, Sprowl J, Stahl S, Yue W. Regulation of Drug Transport Proteins - From Mechanisms to Clinical Impact; A White Paper on Behalf of the ITC. Clinical Pharmacology and Therapeutics . 2022

    5. Farasyn T, Xu C, Yue W. Development of a Rat Sandwich-Cultured Hepatocytes Model Expressing Functional Human Organic Anion Transporting Polypeptide (OATP) 1B3: A Potential Screening Tool for Liver-Targeting Compounds. Journal of Pharmacy \& Pharmaceutical Sciences. 2021; 24 : 475--483

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Grants

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    6. Post-translational regulation of hepatic transporters organic anion transporting polypeptide (OATP) 1B1 and 1B3 by immunosuppressant cyclosporine A: Implication in Transporter-Mediated Drug-Drug Interactions. Misc Non-Federal. Start Date: 2018. End Date: 2019.

    7. Post-translational regulation of transporters organic anion transporting polypeptides (OATP) 1B1 and 1B3 by immunosuppressant cyclosporine A: Implication in Transporter-Mediated Drug-Drug Interactions . Misc Non-Federal. Start Date: 2017. End Date: 2018.

    8. Administrative amendment of adding human subject research component to current funded R01. NIH. Start Date: 2017. End Date: 2017.

    9. Administrative Supplement for Equipment . NIH. Start Date: 2015. End Date: 2017.

    10. Function and regulation of OATP1B1 and OATP1B3. NIH. Start Date: 2011. End Date: 2017.

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Awards and Honors

                                                                                            1. WiSDMH at OUHSC. Recognition of OUHSC Women in Science Dentistry Medicine and Health. Date: 2022.  

                                                                                            2. Shandong University, China. Sunshine scholarship. Date: 1996.  




Education

                                                                                            1.  Degree: Postdoctoral training. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Date: 2008.  

                                                                                            2.  Degree: Postdoctoral Training. Lineberger Comprehensive Cancer Center, Univeristy of North Carolina at Chapel Hill. Date: 2007.  

                                                                                            3.  Degree: Ph D. Peking Union Medical College and Shandong University, China. Date: 2001.  

                                                                                            4.  Degree: MS. Shandong University, China. Date: 1998.  

                                                                                            5.  Degree: BS. Shandong Agricultural University, China. Date: 1995.