Wei Yue, Ph.D.
Associate Professor
Pharmaceutical Sciences
Phone (405) 271-6593 x47828
Fax (405) 271-7505
Office CPB 328
Email wei-yue@ouhsc.edu
Faculty Website https://sites.google.com/view/yuelab
Summary
My research program focuses on studying novel mechanisms involved in regulation of OATP1B1 and OATP1B3 transport function. The long-term goal of my laboratory is to establish a mechanistic model to predict OATP-mediated drug-drug interactions, toxicities and inter-individual variability in drug response. Multi-disciplinary approaches are utilized including: 1) Sandwich-cultured primary human hepatocytes model; 2) Physiologically based pharmacokinetic (PBPK) modeling approach to assess clinically relevant DDIs; 3) Pharmacogenomics studies of drug transport proteins; 4) Post-translational regulation of OATP transporters; 5) Confocal microscopy to study trafficking of the transport proteins.
Academic Awards
Member, Educators for Excellence
OUHSC
April 2022Publications & Presentations
- 31. Bheda A, Yue W, Gullapalli A, Whitehurst C, Liu R, Pagano J S, Shackelford J. Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling. PloS one. 2009; 4 : e5955
32. Yue W, Abe K, Brouwer K L. Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion. Molecular pharmaceutics. 2009; 6 : 134-43
33. Abe K, Bridges A S, Yue W, Brouwer K L. In vitro biliary clearance of angiotensin II receptor blockers and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in sandwich-cultured rat hepatocytes: comparison with in vivo biliary clearance. The Journal of pharmacology and experimental therapeutics. 2008; 326 : 983-90
34. Yue W, Shackelford J, Pagano J S. cdc2/cyclin B1-dependent phosphorylation of EBNA2 at Ser243 regulates its function in mitosis. Journal of virology. 2006; 80 : 2045-50
35. Yue W, Gershburg E, Pagano J S. Hyperphosphorylation of EBNA2 by Epstein-Barr virus protein kinase suppresses transactivation of the LMP1 promoter. Journal of virology. 2005; 79 : 5880-5
Grants
- 1. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . NIH. Start Date: 2022. End Date: 2026.
2. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . Misc Non-Federal. Start Date: 2022. End Date: 2022.
3. Lysine Acetylation: A novel mechanism governing organic anion transporting polypeptides OATP1B1- and OATP1B3-mediated transport. Misc Non-Federal. Start Date: 2021. End Date: 2022.
4. Elucidating novel mechanism underlying OATP1B1/1B3-mediated drug-drug interactions . Non-federal. Start Date: 2019. End Date: 2020.
5. Characterize ADME of compound X. Non-federal. Start Date: 2019. End Date: 2020.
Awards and Honors
- 1. WiSDMH at OUHSC. Recognition of OUHSC Women in Science Dentistry Medicine and Health. Date: 2022.
2. Shandong University, China. Sunshine scholarship. Date: 1996.
Education
- 1. Degree: Postdoctoral training. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Date: 2008.
2. Degree: Postdoctoral Training. Lineberger Comprehensive Cancer Center, Univeristy of North Carolina at Chapel Hill. Date: 2007.
3. Degree: Ph D. Peking Union Medical College and Shandong University, China. Date: 2001.
4. Degree: MS. Shandong University, China. Date: 1998.
5. Degree: BS. Shandong Agricultural University, China. Date: 1995.
Administrative Assignments
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