Vibhuti Agrahari, Ph.D.

Assistant Professor

Pharmaceutical Sciences

Phone 405-271-6751 x47244

Fax 405-271-7505

Office CPB 325

Email vibhuti-agrahari@ouhsc.edu


Summary

My research focuses on long-term drug delivery by designing innovative systems such as nanocarriers, micelles, and hydrogels using biomaterials. The research activities include rationale design, optimization, and evaluation of the nanoformulations for local, targeted and sustained delivery of biotherapeutic and small molecule drugs using stimuli-responsive polymers, natural polymers, block- and random- copolymers, etc. The ultimate goal of my research laboratory is to develop biomaterials that can provide selective, controlled, non-toxic, biodegradable, and stimuli-responsive platforms to target therapeutic agents to the sites of ocular and inner ear diseases. My laboratory is specialized in the area of (a) sustained delivery of protein/antibodies for the back of eye diseases. (b) non-invasive treatment, and prevention of vision loss due to ocular injuries. (c) next-generation therapeutics for anterior segment ocular diseases (d) nanotherapeutic approaches to provide a prophylactic cure for Chemotherapeutic-Induced Ototoxicity (CIO). 




Grants

New Investigator Grant: "Bio-responsive NanoSensoGel for Prevention of Cisplatin-induced Ototoxity and Hearing Loss"

Presbyterian Health Foundation

07/01/2021 - 06/30/2022

CFAR Grant: "ROS-responsive NanoSensoGel for Prevention of Cistplatin-Induced Ototoxicity and Hearing Loss"

Capita Foundation

11/01/2021 - 12/31/2022


Publications & Presentations

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    6. Burnouf T, Agrahari V, Agrahari V. Extracellular Vesicles As Nanomedicine: Hopes And Hurdles In Clinical Translation. INTERNATIONAL JOURNAL OF NANOMEDICINE. 2019; 14 : 8847-8859

    7. Li G, Lee C, Agrahari V, Wang K, Navarro I, Sherwood J M, Crews K, Farsiu S, Gonzalez P, Lin C, Mitra A K, Ethier C R, Stamer W D. In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019; 116 : 1714-1722

    8. Agrahari V, Burnouf P, Burnouf T, Agrahari V. Nanoformulation properties, characterization, and behavior in complex biological matrices: Challenges and opportunities for brain-targeted drug updates delivery applications and enhanced translational potential. ADVANCED DRUG DELIVERY REVIEWS. 2019; 148 : 146-180

    9. Agrahari V, Youm I, Agrahari V. Special Issue on Advanced Drug Delivery Approaches for Inner Ear Therapeutics. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2019; 126 : 1-2

    10. Agrahari V, Agrahari V. Advances and applications of block-copolymer-based nanoformulations. DRUG DISCOVERY TODAY. 2018; 23 : 1139-1151

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Grants

    1. Bio-responsive Nano-SensoGel for Prevention of Chemotherapy-Induced Ototoxicity and Hearing Loss . Non-federal. Start Date: 2021. End Date: 2022.




Awards and Honors

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                                                                                            1. American Association Colleges of Pharmacy. American Association Colleges of Pharmacy – New Investigator Award . Date: 2023.  

                                                                                            2. University of Missouri Kansas City, Kansas City, MO. Board of Directors, GAF Women Council. Date: 2022.  

                                                                                            3. Shenandoah University. Bernard J. Dunn, Jr. Faculty Research Award. Date: 2018.  

                                                                                            4. Shenandoah University. Single Discipline Faculty Development Award. Date: 2018.  

                                                                                            5. Society for Laboratory Automation Science. Tony B. Academic Travel Award. Date: 2017.  

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Education

                                                                                            1.  Degree: Ph D. University of Missouri- Kansas City. Date: 2017.  

                                                                                            2.  Degree: M. Pharm.. Shri G.S. Institute of Technology & Science, India . Date: 2008.  

                                                                                            3.  Degree: B. Pharm. Shri G.S. Institute of Technology & Science, India . Date: 2005.