Alexander Mdzinarishvili, Ph.D.
My current research interest is brain stroke (brain ischemia and edema). I have extended experience in experimental research on brain stroke and brain edema in different MCAO (middle cerebral artery occlusion) animal models (permanent and transient). My research is focusing on the development of new neuroprotective therapeutic strategies to minimize brain stroke-induced cell death and optimize cell self-repair in brain infarct areas. Based on that a second my current research interest is neurogenesis. I have extended experience in experimental research on neural stem cells: proliferation, migration and differentiation in the different brain regions. Neurogenesis and neuronal self-repair mechanisms offer potential therapeutic avenues to pursue in attenuating the deleterious outcomes normally associated with brain stroke and stroke-associated brain edema. New compounds with neuroprotective properties, and/or novel drug delivery systems, such as nanoparticles may stimulate and enhance proliferation and migration of neural stem cells to the brain stroke lesion areas. This ability of neuronal stem cells to integrate into various brain regions, and the modulation of this property by pharmacological intervention, may offer hope for the development of restorative therapies for ischemic, traumatic, and neurodegenerative brain diseases (Brain Stroke, TBI, Alzheimer, Parkinson, Multiple Sclerosis, etc.).
Education & Experience
Ph.D. in Physiology and Pharmacology
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia1990
M.S. in Physiology
Institute of Physiology, Georgian Academy of Science, Tbilisi (Georgia)1985
B.S. in Biology
Georgia State University, Tbilisi (Georgia)1980
Publications & Presentations
- Sadana P, Coughlin L, Burke J, Woods R, Mdzinarishvili A. Anti-edema action of thyroid hormone in MCAO model of ischemic brain stroke: Possible association with AQP4 modulation. Journal of the neurological sciences. 2015; 354 : 37-45
- Mdzinarishvili A, Sutariya V, Talasila P K, Geldenhuys W J, Sadana P. Engineering triiodothyronine (T3) nanoparticle for use in ischemic brain stroke. Drug delivery and translational research. 2013; 3 : 309-17
- Mdzinarishvili A, Sumbria R, Lang D, Klein J. Ginkgo extract EGb761 confers neuroprotection by reduction of glutamate release in ischemic brain. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2012; 15 : 94-102
- Lang D, Kiewert C, Mdzinarishvili A, Schwarzkopf T M, Sumbria R, Hartmann J, Klein J. Neuroprotective effects of bilobalide are accompanied by a reduction of ischemia-induced glutamate release in vivo. Brain research. 2011; 1425 : 155-63
- Kiewert C, Mdzinarishvili A, Hartmann J, Bickel U, Klein J. Metabolic and transmitter changes in core and penumbra after middle cerebral artery occlusion in mice. Brain research. 2010; 1312 : 101-7