Aditya D. Joshi, Ph.D.

Assistant Professor

Pharmaceutical Sciences

Phone 405-271-6593 x 47471

Fax 405-271-7505

Email aditya-joshi@ouhsc.edu

Faculty Website www.joshilaboratory.org


Summary

My research is focused on understanding Aryl hydrocarbon Receptor (AhR) signaling in normal liver physiology as well as in plethora of hepatic and metabolic diseases. The AhR is a ligand-activated transcription factor, historically studied in the context of exogenous ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) induced toxicity. We have demonstrated that in contrast to the toxicity exhibited by exogenous AhR agonists, the endogenous AhR ligand, cinnabarinic acid induced expression of AhR target gene, stanniocalcin 2 is responsible for hepatoprotection against chemical, environmental and pharmacological stressors both in vitro and in vivo. Our long-term objectives are to mechanistically study repertoire of AhR target genes in the context of liver and metabolic diseases and to develop a translational approach to AhR biology by identifying and characterizing therapeutically useful endogenous AhR agonists to ameliorate hepatic injury. To achieve our long-term goal my research employs cutting-edge cellular, molecular and biochemical methodologies as well as utilizes innovative genome-wide technologies such as next-generation sequencing (RNA, ChIP and ATAC-seq) and CRISPR mediated genome editing. 




Publications & Presentations

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    16. Lee C S, Georgiou D K, Dagnino-Acosta A, Xu J, Ismailov I I, Knoblauch M, Monroe T O, Ji R, Hanna A D, Joshi A, Long C, Oakes J, Tran T, Corona B T, Lorca S, Ingalls C P, Narkar V A, Lanner J T, Bayle J H, Durham W J, Hamilton S L. Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function. The Journal of biological chemistry. 2014; 289 : 25556-70

    17. Jackson D P, Li H, Mitchell K A, Joshi A, Elferink C J. Ah receptor-mediated suppression of liver regeneration through NC-XRE-driven p21Cip1 expression. Molecular pharmacology. 2014; 85 : 533-41

    18. Wilson S R, Joshi A, Elferink C J. The tumor suppressor Kruppel-like factor 6 is a novel aryl hydrocarbon receptor DNA binding partner. The Journal of pharmacology and experimental therapeutics. 2013; 345 : 419-29

    19. Harper, Jr T A, Joshi A, Elferink C J. Identification of stanniocalcin 2 as a novel aryl hydrocarbon receptor target gene. The Journal of pharmacology and experimental therapeutics. 2013; 344 : 579-88

    20. Lanner J T, Georgiou D K, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi A, Chen Z, Yarotskyy V, Oakes J M, Lee C S, Monroe T O, Santillan A, Dong K, Goodyear L, Ismailov I I, Rodney G G, Dirksen R T, Hamilton S L. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nature medicine. 2012; 18 : 244-51

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Grants


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Awards and Honors

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                                                                                            6. American Physiological Society. Robert Gunn Graduate Student Award. Date: 2005.  

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Education

                                                                                            1.  Degree: Ph D. University of Texas Medical Branch. Date: 2008.  

                                                                                            2.  Degree: MS. University of Mumbai. Date: 2002.  

                                                                                            3.  Degree: BS. University of Mumbai. Date: 2000.