Associate Professor of Pharmacology and Toxicology
Department of Pharmaceutical Sciences
Immunopharmacology and immunotoxicology
The research in my laboratory primarily focuses on the positive roles that endogenous cytokines play during the repair or restoration of injured tissues. I am currently investigating these effects in both skin and liver utilizing both in vivo and in vitro models.
The purpose of these studies is two fold: 1) to elucidate the mechanism of, and identify factors involved in, the transcriptional or post-transcriptional regulation of genes modulated by various pro-inflammatory cytokines, and 2) to determine if any of these pro-inflammatory mediators may be useful therapeutically. To investigate the former, we have employed a variety of molecular techniques including, ribonuclease protection assay, genomics arrays, transfection studies, and EMSA. Therapeutic studies have involved the reconstitution of wound healing in immunosuppressed animals (cytokine KO’s or glucocorticoid treated) using specific recombinant cytokines, or gene therapy utilizing unique expression plasmids.
Education & Experience
BA Central Washington University Chemistry/Biology
Ph.D. Washington State University Pharmacology/Toxicology
Honors & Service
OUHSC Provost's Junior Faculty Research Award, 2005
Selected Publications & Presentations
Luckett-Chastain LR, Mickle-Kawar BM, Ihnat MI, Gallucci RM. SOCS3 modulates IL-6R signaling preference in dermal fibroblasts. J Interferon Cytokine Res 2012; 32(5): 207-215.
Luckett-Chastain LR, Gallucci RM. Interleukin (IL)-6 modulates transforming growth factor-beta expression in skin and dermal fibroblasts from IL-6-deficient mice. Br J Dermatol 2009; 161(2): 237-248.
Larabee JL, Hocker JR, Cheung JY, Gallucci RM, Hanas JS. Serum profiling of rat dermal explosure to JP-8 fuel reveals an acute-phase response. Toxicology Mechanisms and Methods 2008; 18:41-51.
Luckett LR, Gallucci RM. Interleukin 6 modulates migration and MMP function in dermal fibroblasts from IL6-KO mice. Br. J. Derm, 156(6): 1163-1167, 2007.
Saban MR, Wallis G, Simpson C, Davis C, Knowlton N, Frank MB, Centola M, Gallucci RM, and Saban R, Time-course of mouse bladder inflammation and urinary cytokine release in response to intravesical instillation of BCG, TNF-alpha, and LPS. BMC Immunology May 16, 8:6, 2007.
Current Grants Awarded
- 8/1/2010-7/31/2013 OCAST/Regular - The role of IL-6 in diabetic wound healing.
4/1/2007 - 3/31/2008 DHHS - Gender differences in liver IL 6R expression
6/1/2006 - 5/31/2007 American Foundation for Pharmaceutical Education (AFPE) - AFPE 2006 Gateway Research Scholarship Program
5/1/2004-4/30/2009 NIH/NIGMS - Identification of an IL-6 induced keratinocyte motogen
6/1/2003 - 5/31/2005 Oklahoma State Regents for Higher Education (OSRHE) - Potentiation of noise induced hearing loss by jet fuel (JP-8) exposure
6/1/2002 - 5/30/2005 DOD - Potential of noise induced hearing loss by jet fuel (JP-8)