Randle Gallucci , Ph.D.
Associate Professor of Pharmacology and Toxicology
Department of Pharmaceutical Sciences
Research Summary
Specialties
Immunopharmacology and immunotoxicology
Research Interests
The research in my laboratory primarily focuses on the positive roles that endogenous cytokines play during the repair or restoration of injured tissues. I am currently investigating these effects in both skin and liver utilizing both in vivo and in vitro models.
The purpose of these studies is two fold: 1) to elucidate the mechanism of, and identify factors involved in, the transcriptional or post-transcriptional regulation of genes modulated by various pro-inflammatory cytokines, and 2) to determine if any of these pro-inflammatory mediators may be useful therapeutically. To investigate the former, we have employed a variety of molecular techniques including, ribonuclease protection assay, genomics arrays, transfection studies, and EMSA. Therapeutic studies have involved the reconstitution of wound healing in immunosuppressed animals (cytokine KO’s or glucocorticoid treated) using specific recombinant cytokines, or gene therapy utilizing unique expression plasmids.
Education & Experience
Education
BA Central Washington University Chemistry/Biology
Ph.D. Washington State University Pharmacology/Toxicology
Honors & Service
OUHSC Provost's Junior Faculty Research Award, 2005
Selected Publications & Presentations
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Larabee JL, Hocker JR, Cheung JY, Gallucci RM, Hanas JS. Serum profiling of rat dermal explosure to JP-8 fuel reveals an acute-phase response. Toxicology Mechanisms and Methods 2008; 18:41-51.
- Luckett LR, Gallucci RM. Interleukin 6 modulates migration and MMP function in dermal fibroblasts from IL6-KO mice. Br. J. Derm, 156(6): 1163-1167, 2007.
- Saban MR, Wallis G, Simpson C, Davis C, Knowlton N, Frank MB, Centola M, Gallucci RM, and Saban R, Time-course of mouse bladder inflammation and urinary cytokine release in response to intravesical instillation of BCG, TNF-alpha, and LPS. BMC Immunology May 16, 8:6, 2007.
- Gallucci RM, Mickle BM. Inflammatory cytokine expression patterns in rat skin exposed to JP-8 jet fuel. Am. J. Pharm. Tox., 1(3):48-53, 2006.
- Gallucci RM, Lee EG, and Tomasek JJ. Interleukin 6 modulates alpha-smooth muscle actin expression in dermal fibroblasts. J. Inv. Derm. Mar;126(3):561-568, 2006.
Current Grants Awarded
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NIH - Identification of an IL-6-induced keratinocyte motogen (minority supplement included)
Completed Grants
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4/1/2007 - 3/31/2008 DHHS - Gender differences in liver IL 6R expression
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6/1/2006 - 5/31/2007 American Foundation for Pharmaceutical Education (AFPE) - AFPE 2006 Gateway Research Scholarship Program
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6/1/2003 - 5/31/2005 Oklahoma State Regents for Higher Education (OSRHE) - Potentiation of noise induced hearing loss by jet fuel (JP-8) exposure
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6/1/2002 - 5/30/2005 DOD - Potential of noise induced hearing loss by jet fuel (JP-8)