People

Wei  Yue , Ph.D.

Assistant Professor

Department of Pharmaceutical Sciences

Phone (405) 271-6593  x47828
Fax (405) 271-7505
Office   CPB 328
Email wei-yue@ouhsc.edu

Research Summary

Hepatic drug transport proteins are now recognized as important clinically-relevant determinants of variable drug responsiveness and unexpected drug-drug interactions (DDIs). Organic anion transporting polypeptides (OATPs) are major hepatic transport proteins that mediate the uptake, from blood into the liver, of a diverse array of endogenous compounds (e.g. bile acids), environmental toxins, and many drugs, including lipid-lowering statins, antibiotics, immunosuppressants, cardiac glycosides, antidiabetic and anticancer agents. Dysfunction of OATP1B1 and OATP1B3 is closely related with altered drug pharmacokinetics and toxicity. Genetic polymorphisms of OATP1B1 and OATP1B3 that have decreased transport function are associated with markedly increased plasma concentrations and systemic exposure of many drugs.
Dr. Yue directs an NIH-funded research program focused on studying the role of drug transport proteins, including OATPs, in drug disposition, aiming to predict transporter-mediated drug-drug and drug-disease interactions and toxicities. Multi-disciplinary approaches are utilized in the Yue research program including: 1) characterization of drug-drug interactions and pharmacokinetics of drug transport using in vitro models (e.g. cultured rat and human hepatocytes, transporter-over expressing cell lines); 2) recombinant viral vector-mediated gene transfer and RNA interference (RNAi); 3) pharmacogenomic studies; and 4) contemporary molecular biology techniques.

Education & Experience

Education:
  • 1998-2001, Ph.D., Developmental Biology. Joint PhD program in Peking Union Medical College and Shandong University, China.
  • 1995-1998, M.S., Developmental Biology. Shandong University, China.
  • 1991-1995, B.S., Plant Pathology. Shandong Agricultural University, China.

Academic Experience:

  • 2012-Present, Assistant Professor, Dept. of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, OK.
  • 2012-Present, Member of Peggy and Charles Stephenson Cancer Center. The University of Oklahoma Health Sciences Center, Oklahoma City, OK.
  • 2011-2012, Associate Member of Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • 2008-2012, Research Assistant Professor, Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • 2007-2008, Postdoctoral Research Associate, Division of Pharmacotherapy and Experimental Therapeutics, UNC Eschelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • 2002-2007, Postdoctoral Research Associate, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

Honors & Service

Honors and Awards:
  • Wei Yue, Principal Investigator, NIH R01 award (funding period 2011-2016), "Function and regulation of OATP1B1 and OATP1B3," sponsored by NIGMS/NIH.
  • Wei Yue, Principal Investigator, University research council small grant program award (funding period 2009-2012), sponsored by UNC at Chapel Hill.
  • Wei Yue, Principal Investigator, North Carolina Translational and Clinical Sciences (NC Tracs) Institute award (funding period 2009-2010).

Professional Membership and Service:

  • 2012-present, Member, International Society for the Study of Xenobiotics.
  • 2010-present, Steering Committee, AAPS Drug Transport Focus Group.
  • 2007-present, Member, American Association of Pharmaceutical Scientists (AAPS).
  • AAPS 2004-2006, Member, American Society for Microbiology (ASM).
  • Manuscript referee for Molecular Pharmaceutics and Journal of Natural Products.
  • Moderator of Poster Podium Session of AAPS Workshop on Drug Transporters in ADME: From the Bench to the Bedside, Bethesda, 2013.
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Selected Publications & Presentations

  1. Alam K, Pahwa S, Wang X, Zhang P, Ding K, Abuznait A, Li L, Yue W,. Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions Molecular Pharmaceutics. 2016; 13: 839851.
  2. Kupiec T, Yue W. DRUG INTERACTIONS Prentice Hall. In Press; 3:
  3. Farasyn T. Rapid down-regulation of organic anion transporting polypeptide (OATP) 1B3 transport function by phosphorylation modulators in sandwich-cultured hepatocytes: A novel mechanism of OATP1B3 inhibition Drug Metabolism Reviews. 2015; 47(S1): 259.
  4. Farasyn T, John P, Kai D, Yue W. Rapid down-regulation of organic anion transporting polypeptide (OATP) 1B3 transport function by phosphorylation modulators in sandwich-cultured hepatocytes: a novel mechanism of OATP1B3 inhibition Drug Metabolism Reviews. 2015; 47(S1):
  5. Alam K,. Indirect inhibition of organic anion transporting polypeptide (OATP) 1B3-mediated transport by proteasome inhibitor bortezomib In Press;
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Current Grants Awarded

  • R01 award (funding period 2011-2016). "Function and regulation of OATP1B1 and OATP1B3," sponsored by NIH/NIGMS.