People

Randle  Gallucci , Ph.D.

Associate Professor of Pharmacology and Toxicology

Department of Pharmaceutical Sciences

Phone (405) 271-6593  x47188
Fax (405) 271-7505
Office   CPB 333
Email Randy-Gallucci@ouhsc.edu

Research Summary

Specialties
Immunopharmacology and immunotoxicology
Research Interests
The research in my laboratory primarily focuses on the positive roles that endogenous cytokines play during the repair or restoration of injured tissues. I am currently investigating these effects in both skin and liver utilizing both in vivo and in vitro models.
The purpose of these studies is two fold: 1) to elucidate the mechanism of, and identify factors involved in, the transcriptional or post-transcriptional regulation of genes modulated by various pro-inflammatory cytokines, and 2) to determine if any of these pro-inflammatory mediators may be useful therapeutically. To investigate the former, we have employed a variety of molecular techniques including, ribonuclease protection assay, genomics arrays, transfection studies, and EMSA. Therapeutic studies have involved the reconstitution of wound healing in immunosuppressed animals (cytokine KOs or glucocorticoid treated) using specific recombinant cytokines, or gene therapy utilizing unique expression plasmids.

Education & Experience

Education
BA Central Washington University Chemistry/Biology
Ph.D. Washington State University Pharmacology/Toxicology

Honors & Service

OUHSC Provost's Junior Faculty Research Award, 2005
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Selected Publications & Presentations

  1. Luckett-Chastain L R, Cottrell M L, Kawar B M, Ihnat M, Gallucci R. Interleukin-6 modulates transforming growth factor-beta II function and in epidermal keratinocytes Experimental Dermatology/Wiley. 2016; ePub:
  2. Lee E G, Bastian A, Luckett-Chastain L R, Kawar B M, Gallucci R. Interleukin 6 receptor function in skin and isolated keratinocytes is modulated by hyperglycemia Inflammation Research/Springer. In Press;
  3. Lee E G, Mickle-Kawar B M, Gallucci R. IL-6 deficiency exacerbates skin inflammation in a murine model of irritant dermatitis. Journal of immunotoxicology. 2013; 10: 192-200.
  4. Lee E G, Mickle-Kawar B M, Reinke L A, Gallucci R. Estrogen suppresses heptatic I?B expression during short-term alcohol exposure. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2012; 61: 1053-61.
  5. Luckett-Chastain L R, Ihnat M, Mickle-Kawar B M, Gallucci R. SOCS3 modulates interleukin-6R signaling preference in dermal fibroblasts. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2012; 32: 207-15.
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Current Grants Awarded

NIH-NIOSH/CDC, R01 (09/01/2013-08/31/2017) "The role of IL-6 receptor in irritant dermatitis." Principal investigator