Goverdhan Sachdev , Ph.D.
George Lynn Cross Professor of Medicinal Chemistry
Department of Pharmaceutical Sciences
Research Summary
Research Interests
The focus of research in our laboratory is in the area of cystic fibrosis (CF). CF is the most lethal genetic disease in Caucasians and is characterized by production of excessive amounts of viscous mucus secretions in the airways of the patients. To date the causes of CF airway obstruction is not understood. In addition, the excess mucus in the lungs leads to chronic bacterial infections. Chronic colonization of CF airways with gram negative bacterium Pseudomonas aeruginosa is considered the principal cause of death of CF patients. In our research, we are investigating the molecular basis of P. aeruginosa specific Binding to CF airway mucins.
Our laboratory is also investigating the mechanism of hypersecretion of mucus in CF patients. We are investigating the role of inflammatory mediators and endotoxin in the hypersecretion of mucus in CF.
Our laboratory is investigating the mechanisms of hypersecretion of mucus in CF patients as well as mechanisms that lead to chronic bacterial infections. We are also determining the genomic organization of recently discovered MUC8 airway mucin gene from our laboratory. The determination of promoter region of the MUC8 gene would help understand the regulation of MUC8 gene expression in the disease and healthy states. Our long-term goals are to control hypersecretion of mucus in cystic fibrosis as well as to treat or prevent chronic bacterial infections in CF.
Our laboratory has reported the identification of novel airway mucin gene MUC8. We are investigating the role of MUC8 gene product in the hypersecretion of airway mucus in CF. We are determining the genomic organization of the recently discovered MUC8 gene from our laboratory, We determination of promotor and enhancer regions of the MUC8 gene would help in the understanding of regulation of MUC8 gene expression in the disease and healthy states. Our Long-term goals are to control rate of mucus secretion in cystic fibrosis as well as to treat and/or prevent chronic bacterial infections in CF and thus increase the quality of life for CF patients.
Education & Experience
- University of Delhi, B.Sc. (Honors) Chemistry, 1961
- University of Delhi, M.Sc. Chemistry, 1963
- University of Delhi, Ph.D. Chemistry, 1967
- Postdoctoral Research Associate, Department of Biology, Yale University, 1968-1975
- Assistant Member, Biomembrane Research Program, Oklahoma Medical Research Foundation,, 1975-1984
- Associate Research Professor, Department of Medicinal Chemistry and Pharmacodynamics, College of Pharmacy, University of Oklahoma HSC
- Associate Professor, Department of Medicinal Chemistry and Pharmacodynamics, College of Pharmacy, University of Oklahoma HSC, 1988-1991
- Professor, Department of Medicinal Chemistry and Pharmodynamics, College of Pharmacy, University of Oklahoma HSC, 1991- Present
- George Lynn Cross Professor, Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma HSC, 1994 - Present
- Member, Oklahoma Center for Medical Glycobiology, University of Oklahoma HSC, 1999 - Present
Honors & Service
Selected Publications & Presentations
-
Xia B, Feasley CL, Sachdev GP, Smith DF, Cummings RD. Glycan reductive isotope labeling for quantitative glycomics. Analytical Biochemistry 2009; 387: 162-170.
-
Xia B, Feasley CL, Sachdev GP, Smith DF, Cummings RD. Glycan reductive isotope labeling for quantitative glycomics. Analysitcal Biochemistry 2009; 387: 162-170.
-
Xia B, Sachdev GP, Cummings RD. Pseudomonas aeruginosa mucoid strain 8830 binds glycans containing sialyl lewis X epitope. J Glycoconjugate 2007; 24: 87-95.
- Pseudomonas aeruginosa Mucoid Strain 8830 Binds Glycans Containing the Sialyl Lewis X Epitope. Xia B, Sachdev GP, Cummings RD. Glycoconjugate Journal, 2006 (in press).
-
Damera G, Xia B, Sachdev GP. IL-9 modulated MUC4 gene and glycoprotein expression in airway epithelial cells. Bioscience Reports 2006; 26:56-67.
Current Grants Awarded
-
Oklahoma Center for the Advancement of Science and Technology (OCAST) - Novel Pharmacological treatments of cystic fibrosis (CF) lung Pseudomonas aeruginosa (Pa) infection
Completed Grants
-
8/1/2003 - 7/31/2005 NIH - Biochemical role of airway mucins in cystic fibrosis