David W.A. Bourne , Ph.D.
Professor of Pharmaceutics
Department of Pharmaceutical Sciences
Research Summary
Research Interests
Research interests include the study of pharmacokinetic models; especially physiologically based models, models involving protein binding, pharmacodynamic models and the development of computer programs for pharmacokinetic analysis. Recent work has included the development of models for cephalosporin and sulfonamide disposition including protein binding; oral and Intranasal administration of selected drugs and comparison with IV administration; and the influence of zero gravity of drug absorption and disposition. Computer programs include BOOMER a general purpose non-linear regression and simulation program written in FORTRAN for the Macintosh, IBM PC desktop computers, and the VAX mainframe computer. Ancillary to the study of pharmacokinetic models is the development of drug analysis techniques, especially high pressure liquid chromatography. Use of the Internet as a research and teaching resource is a major interest.
Education & Experience
- 1967 - Diploma of Pharmacy, Victorian College of Pharmacy
- 1971 - B.Pharm., Victorian Institute of Colleges
- 1973 - M.S.(Honors), University of Kansas
- 1974 - Ph.D., University of Kansas - Victorian College of Pharmacy (Intersearch). Thesis, "Acronycine esters as Pro-Drugs. Inhibition of Hydrolysis by Complexation"
- 1974-77 - Postdoctoral Fellowship, College of Pharmacy, Univ of Kentucky, Lexington
Selected Publications & Presentations
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Maxwell LK, Bentz BG, Bourne DWA, Erkert RS. Pharmacokinetics of valacyclovir in the adult hore. J Vet Pharmacol Therap 2008; 31:312-320.
- Vanapalli, S.R., Kambhampati, S.P., Putcha, L., and Bourne, D.W.A. 2001 A Liquid Chromatographic Method for the Simultaneous Determination of Promethazine and Three of Its Metabolites in Plasma Using Electrochemical and UV Detectors, J. Chromatographic Sciences, 39(2), 70-72
- Ramanathan, R., Geary, R.S., Bourne, D.W.A., and Putcha, L. 1998 Bioavailability of intranasal promethazine doage forms in dogs, Pharmacological Research, 38(1), 35-39
- Kwon, K.I. and Bourne, D.W.A. 1997 Gastrointestinal Absorption of Phenytoin from an Oil-in-water Microemulsion, Arch. Pharm. Res., 20(5), 480-485
- Bourne, D.W.A. 1997 Using the Internet as a Pharmacokinetic Resource, Clinical Pharmacokinetics, 33, 153-160
Current Grants Awarded
- NIH - Cochlear therapy through magnetic targeted drug delivery