Assistant Professor of Research
Department of Pharmaceutical Sciences
I am intrigued by the multiple functions of the imidazole-containing peptide derivatives, such as carcinine. I am particularly interested by their aldehyde-quenching effect since it can mimic the detoxification role of the photoreceptor inner segment RDHs. I have made the observation that carcinine can reach high levels in the retina after topical administration through eye drops. This, combined with the strong neuroprotective effect of carcinine, offers therapeutic potentials for progressive retinopathies that involve oxidative damage in their pathogenesis.
Education & Experience
- Postdoctoral Fellow, University of Texas, Dallas. Molecular Genetics. 2004
- Ph.D., Endocrinology. University of Paris XI, France. 1998.
- M.S., Cell Biology. University of Paris VII. France. 1993.
- B.S., Cell Biology. University of Paris VII. France. 1992.
- Assistant Professor of Research, Dept. of Pharmaceutical Sciences, OU College of Pharmacy. OKC, OK. 2011-present.
- Assistant Professor of Research, Dept. of Ophthalmology, OU Health Sciences Center. OKC, OK. 2004-2011.
- Postdoctoral Researcher, Dept. of Molecular Genetics. Univ. of Texas Southwestern Medical Center. Dallas, TX. 1998-2004.
- Graduate Student, Laboratoire d'Endrocrinologie Metabolisme et Developpement, CNRS UPR 1524, Meudon, France. 1994-1998.
- Research Assistant, Laboratoire de Pharmacologie et des Transports Ioniques, Univ. of Paris VII. France. 1991-1992.
Honors & Service
Awards: Travel awards to present results in international meetings, from the Association for Research in Vision and Ophthalmology Foundation (2006), the National Eye Institute (2004), the International Society for Eye Research (2004), and the Keystone Symposia (1998).
Selected Publications & Presentations
Griffith GL, Kasus-Jacobi A, Lerner MR, Pereira HA. Corneal wound healing, a newly identified function of CAP37, is mediated by protein kinase C delta. Invest Ophthalmol Vis Sci 2014; 55: 4886-4895.
Griffith GL, Russell RA, Kasus-Jacobi A, Thavathiru E, Gonzalez ML, Logan S, Pereira HA. CAP37 activation of PKC promotes human corneal epithelial chell chemotaxis. Invest Ophthalmol Vis Sci 2013; 10.1167/iovs. 13-12054.
Current Grants Awarded
- Oklahoma Health Research Program, OCAST. "Therapeutic use of carcinine in progressive retinopathy."
- NIH/NCRR/COBRE. "Mentoring vision research in Oklahoma." Subproject: "Photoreceptor retinol dehydrogenases and vision."
- OK/NSF/EPSCoR. "Functional analysis of SREBPs in photoreceptors."
- NIH/NEI. "Detoxification role of retinol dehydrogenases RDH11 and RDH12."
- College of Medicine Alumni Association. "Generation of a new mouse model of Leber Congenital Amaurosis Type 13."