Pharmacokinetic Properties of Probestin-Based APN-Targeted Agents Could be Optimized
7/2/2012 | Return to All Current News
Drs. Michael Ihnat, Vibhudutta Awasthi and Hariprasad Gali co-authored "Synthesis and biodistribution studies of technetium-99m-labeled aminopeptidase N inhibitor conjugates," which is now published in Bioorganic & Medicinal Chemistry Letters 2012; 22(14): 4567-4570.
The results of their study revealed that the Tc-99m labeled probestin conjugate preferentially excreted via the renal route when an aspartic acid residue was added to the linker (conjugate 4). These results suggest that the pharmacokinetic properties of probestin-based APN-targeted agents could be optimized by adding an appropriate amino acid residue in between the linker and the payload.